abstract：Background:In previous study, we found elevated serum total lactate dehydrogenase (LDH) before correction of pectus excavatum and a decrease in total LDH after the deformity correction. In the present study, we analyzed total LDH activity and its isoenzyme patterns to investigate the causes of these laboratory findings...

journal_title：Journal of thoracic disease

authors： Jeong SC,Kim JJ,Kim YH,Kim IS,Han JW

更新日期：2019-10-01 00:00:00

abstract：:Chronic dyspnoea, or breathlessness for more than four weeks duration, is a common symptom in adults presenting to primary and tertiary care. It often presents a diagnostic challenge due to the wide spectrum of underlying disease, which is multifactorial in approximately one third of cases. Challenges in diagnosis inc...

journal_title：Journal of thoracic disease

authors： Ferry OR,Huang YC,Masel PJ,Hamilton M,Fong KM,Bowman RV,McKenzie SC,Yang IA

更新日期：2019-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) primarily affects the lungs but due to the accompanying chronic systematic inflammation and the symptoms associated with the disease there are many extrapulmonary effects which include complex physical and metabolic adaptations. These changes have been associated with reduc...

journal_title：Journal of thoracic disease

authors： Collins PF,Yang IA,Chang YC,Vaughan A

更新日期：2019-10-01 00:00:00

abstract：:Rejection is a major complication following lung transplantation. Acute cellular rejection, lymphocytic bronchiolitis, and antibody-mediated rejection (AMR) are all risk factors for the subsequent development of chronic lung allograft dysfunction (CLAD). Acute cellular rejection and lymphocytic bronchiolitis have well...

journal_title：Journal of thoracic disease

authors： Parulekar AD,Kao CC

更新日期：2019-09-01 00:00:00

abstract：:Lung transplantation (LTx) is routinely performed with sacrifice of the bronchial arterial circulation. We review bronchial artery anatomy and surgical technique for LTx with direct bronchial arterial revascularization (BAR). We also update the published clinical experience, including from our center, of LTx with BAR....

journal_title：Journal of thoracic disease

authors： Yun JJ,Unai S,Pettersson G

更新日期：2019-09-01 00:00:00

abstract：:Kehlet first introduced the notion of enhanced recovery after surgery (ERAS). Moreover, in the last years, the fast-track programmes demonstrated a reduction of complications and the hospital length of stay in general surgery. ERAS involves a multidisciplinary to development the value of care introducing the evidence-...

journal_title：Journal of thoracic disease

authors： Bertolaccini L,Brunelli A

更新日期：2019-09-01 00:00:00

abstract：Background:Esophageal cancer is one of the most malignant gastroenterological cancers. To improve the treatment outcomes of patients with esophageal squamous cell carcinoma (ESCC), a biomarker capable of predicting the malignant potential of the cancer cells is needed. The aim of the present study was to investigate th...

journal_title：Journal of thoracic disease

authors： Sakakibara T,Ozawa S,Oguma J,Nakui M,Yamamoto S,Makuuchi H,Kajiwara H,Nakamura N

更新日期：2019-09-01 00:00:00

abstract：Background:Video-assisted thoracoscopic surgery has been identified as priori choice compared with open approaches in esophageal cancer surgery. With the developments in the Da Vinci robotic system, the robot-assisted minimally invasive esophagectomy (RAMIE) has been increasingly popular. However, whether RAMIE could b...

journal_title：Journal of thoracic disease

authors： Chen J,Liu Q,Zhang X,Yang H,Tan Z,Lin Y,Fu J

更新日期：2019-09-01 00:00:00

abstract：Background:Acute myocardial infarction (AMI) is an acute disease with high mortality and seriously threatens human health. The identification of new effective biological markers for AMI is a prerequisite for treatment. Most proteomic studies have focused on atherosclerotic plaques, vascular cells, monocytes and platele...

journal_title：Journal of thoracic disease

authors： Xu S,Jiang J,Zhang Y,Chen T,Zhu M,Fang C,Mi Y

更新日期：2019-09-01 00:00:00

abstract：:Extended thymectomy has been considered the goal of surgery for myasthenia gravis (MG) mainly due to the existence of ectopic thymic tissue. Recently, ectopic thymic tissue has attracted increasing attention in patients with MG following thymectomy. However, the specific role of ectopic thymic tissue in patients with ...

journal_title：Journal of thoracic disease

authors： Li F,Tao Y,Bauer G,Elsner A,Li Z,Swierzy M,Englisch J,Meisel A,Ismail M,Rückert JC

更新日期：2019-09-01 00:00:00

abstract：Background:Angiolymphatic invasion (ALI) plays an important role in lymph node metastasis. The presence of an ALI predicts a high risk for lymph node metastasis and a poor prognosis in patients with lymph node negative esophageal carcinoma. The independent prognostic value of ALI in node-negative patients remains contr...

journal_title：Journal of thoracic disease

authors： Wang A,Tan Y,Zhang Y,Xu D,Fang Y,Chen X,Wang S

更新日期：2019-08-01 00:00:00

abstract：Background:Pulmonary metastasectomy (PM) has commonly been performed in patients with controlled metastatic sarcoma. We reviewed our single-institution experience with pulmonary resections for sarcoma to analyse clinical outcome and to identify prognostic factors associated with patient survival. Methods:All sarcoma p...

journal_title：Journal of thoracic disease

authors： Dudek W,Schreiner W,Mykoliuk I,Higaze M,Sirbu H

更新日期：2019-08-01 00:00:00

abstract：Background:In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N1 is a heterogeneous entity, and different forms of lymph node involvement may represent different prognoses. For methodological reasons, the 8th edition of the TNM staging system for NSCLC makes no official changes to the ...

journal_title：Journal of thoracic disease

authors： Griff S,Taber S,Bauer TT,Pfannschmidt J

更新日期：2019-08-01 00:00:00

abstract：Background:Clinical practice guidelines (CPGs) provide many recommendations for hyperlipidemia management, but some of them are still debatable. Methods:We applied the six-domain Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument to evaluate the quality of guidelines with lipid management rec...

journal_title：Journal of thoracic disease

authors： Zhou H,Zhang S,Sun X,Yang D,Zhuang X,Guo Y,Hu X,Du Z,Zhang M,Liao X

更新日期：2019-08-01 00:00:00

abstract：Background:Subjects with chronic obstructive pulmonary disease (COPD) present increased mortality and poor health-related quality of life (HRQoL) as compared with the general population. The objective of this study was to evaluate whether an improvement in QoL after 1 year of proper management is a predictor of surviva...

journal_title：Journal of thoracic disease

authors： Havlucu Y,Yorgancıoglu A,Sakar Coskun A,Celık P

更新日期：2019-08-01 00:00:00

abstract：:While management of locally advanced esophageal cancer has mostly involved multimodality therapy, management of clinical T2N0 patients has been more controversial, primarily as a result of inaccurate clinical staging with existing modalities. This review article examines current literature on this topic and provides r...

journal_title：Journal of thoracic disease

authors： Vining P,Birdas TJ

更新日期：2019-08-01 00:00:00

abstract：Background:Pleural effusions are common complications of various diseases. Patients with malignant pleural effusion (MPE) usually face poor prognosis and short life expectancy. Discriminating between MPE and benign pleural effusion remains to be difficult. The aim of our current study was to evaluate whether CD206+CD14...

journal_title：Journal of thoracic disease

authors： Pei XB,Wu XZ,Yi FS,Zhai K,Shi HZ

更新日期：2019-07-01 00:00:00

abstract：Background:Thymic carcinoma (TC) is a rare mediastinal tumor, and patients with stage IV TC have a poor prognosis. No optimal chemotherapeutic regimen has yet been established. In this study, we evaluated the efficacy and safety of S-1 as a salvage mono-therapy in stage IV TC. Methods:Patients with histologically conf...

journal_title：Journal of thoracic disease

authors： Wang CL,Gao LT,Lu CX

更新日期：2019-07-01 00:00:00

abstract：Background:Although robot-assisted minimally-invasive esophagectomy (RAMIE) surgeries are expanding clinically, few studies have reported patients with locally-advanced esophageal cancer who underwent neoadjuvant chemoradiation therapy (nCRT). Methods:From 2013 to 2017, 219 patients with esophageal squamous cell carci...

journal_title：Journal of thoracic disease

authors： Yun JK,Lee IS,Gong CS,Kim BS,Kim HR,Kim DK,Park SI,Kim YH

更新日期：2019-07-01 00:00:00

abstract：Background:Patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations often develop systemic disease progression during treatment with EGFR-tyrosine kinase inhibitors (TKIs). Droplet digital polymerase chain reaction (ddPCR) and amplification refractory mutation system ...

journal_title：Journal of thoracic disease

authors： Li Y,Xu Y,Wu X,He C,Liu Q,Wang F

更新日期：2019-07-01 00:00:00

abstract：Background:Thoracoscopic surgery (TS) has been used more commonly as a less invasive procedure for early-stage non-small cell lung cancer (NSCLC) than conventional thoracotomy (TH) in Japan. However, limited evidential data are available to compare the treatment efficacy of TS and TH. The purpose of this study was to r...

journal_title：Journal of thoracic disease

authors： Nakao M,Ichinose J,Matsuura Y,Nakagawa K,Okumura S,Mun M

更新日期：2019-07-01 00:00:00

abstract：:Alteration of tissue perfusion is a main contributor to organ dysfunction in high-risk surgical patients. The difference between venous carbon dioxide and arterial carbon dioxide pressure (pCO2 gap) has been described as a parameter reflecting tissue hypoperfusion in critically ill patients who are insufficiently resu...

journal_title：Journal of thoracic disease

authors： Huette P,Ellouze O,Abou-Arab O,Guinot PG

更新日期：2019-07-01 00:00:00

abstract：:Minimally invasive extracorporeal circulation (MiECC) technology is characterized by improved biocompatibility due to closed-loop design, minimized priming, and markedly reduced artificial surface. Despite well-evidenced clinical advantages in coronary surgery, MiECC penetration in complex open-heart surgery is low. C...

journal_title：Journal of thoracic disease

authors： Liebold A,Albrecht G

更新日期：2019-06-01 00:00:00

abstract：Background:Recent studies incorporating dose escalated radiation identified heart dose as a predictor of cardiac toxicity in unresectable lung cancer patients. Whether conventionally dosed radiation impacts cardiac events remains unclear. Methods:Stage III lung cancer patients undergoing definitive chemoradiation to 6...

journal_title：Journal of thoracic disease

authors： Ni L,Koshy M,Connell P,Pitroda S,Golden DW,Al-Hallaq H,Hubert G,Kauffman G,McCall A,Malik R

更新日期：2019-06-01 00:00:00

abstract：Background:Preoperative lymphocyte count (pre-LC) predicts the relapse and survival in patients with esophageal squamous cell carcinoma (ESCC), the clinical application of postoperative lymphocyte count (post-LC) change (LCc) remains unclear. Methods:A retrospective analysis of patients with newly diagnosed ESCC who r...

journal_title：Journal of thoracic disease

authors： Song Q,Wu JZ,Wang S

更新日期：2019-06-01 00:00:00

abstract：Background:Robotic lobectomy is widely used for lung cancer treatment. So far, few studies have been performed to systematically analyze the learning curve. Our purpose is to define the learning curve to provide a training guideline of this technique. Methods:A total of 208 consecutive patients with primary lung cance...

journal_title：Journal of thoracic disease

authors： Song G,Sun X,Miao S,Li S,Zhao Y,Xuan Y,Qiu T,Niu Z,Song J,Jiao W

更新日期：2019-06-01 00:00:00

abstract：Background:Sarcopenia is closely associated with surgical complications in patients with certain cancers. In this study we assessed the relationship between sarcopenia and postoperative complications in patients with oesophageal squamous cell carcinoma. Methods:We retrospectively analysed of patients who underwent tho...

journal_title：Journal of thoracic disease

authors： Xu J,Zheng B,Zhang S,Zeng T,Chen H,Zheng W,Chen C

更新日期：2019-06-01 00:00:00

abstract：:Although surgical fixation of rib fractures is increasingly being performed around the world, very little has been published on how to access the chest wall itself. Having performed over one hundred rib fixations in our institution in the past five years, our surgical technique has evolved as more has come to be under...

journal_title：Journal of thoracic disease

authors： Greiffenstein P,Tran MQ,Campeau L

更新日期：2019-05-01 00:00:00

abstract：Background:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become important treatment options for non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutation. However, the detection of EGFR driver mutation is impeded by the lack of adequate tumor tissues, histopathological type...

journal_title：Journal of thoracic disease

authors： Liu YT,Han XH,Xing PY,Hu XS,Hao XZ,Wang Y,Li JL,Zhang ZS,Yang ZH,Shi YK

更新日期：2019-05-01 00:00:00

abstract：Background:To evaluate the influence of tumor depth on preoperative computed tomography (CT) image, and resection margin length on local recurrence after pulmonary metastasectomy of colorectal cancer. Methods:Patients undergoing thoracoscopic pulmonary wedge resection for single pulmonary metastasis of colorectal canc...

journal_title：Journal of thoracic disease

authors： Chung JH,Lee SH,Yi E,Lim JY,Jung JS,Son HS,Sun K

更新日期：2019-05-01 00:00:00

abstract：Background:The development of minimally invasive surgical approaches has revolutionized surgical care and greatly improved surgical outcomes. This study aimed to evaluate the clinical effectiveness of a powered vascular stapler (PVS) during video-assisted thoracoscopic surgery (VATS) lobectomy. Methods:This prospectiv...

journal_title：Journal of thoracic disease

authors： Qiu B,Kang X,Chen KN,Hu J,Li J,Zeng L,Fegelman EJ,Schwiers ML,Creedon EE,Waggoner JR,Ding D,Yang T,Gao S

更新日期：2019-05-01 00:00:00

abstract：Background:Primary ciliary dyskinesia (PCD) is an inherited ciliary motility disorder caused by mutations in at least 40 genes. RSPH9 gene mutations encoding aberrant radial spoke head proteins have been linked with PCD. The clinical spectrum extent of RSPH9 gene mutations remains to date largely unknown. We aimed to d...

journal_title：Journal of thoracic disease

authors： Yiallouros PK,Kouis P,Pirpa P,Michailidou K,Loizidou MA,Potamiti L,Kalyva M,Koutras G,Kyriacou K,Hadjisavvas A

更新日期：2019-05-01 00:00:00

abstract：:Obstructive sleep apnoea (OSA) is a global health problem of increasing prevalence. Effective treatments are available with continuous positive airway pressure (CPAP) therapy and mandibular advancement devices (MAD). However, there is limited long-term adherence to therapy, as CPAP and MAD require permanent usage to a...

journal_title：Journal of thoracic disease

authors： He B,Al-Sherif M,Nido M,Tas R,Beach M,Schwarz EI,Cheng M,Ishak A,Lee K,Shah N,Kent B,Eze-John P,Ratneswaran C,Rafferty G,Williams AJ,Hart N,Luo Y,Moxham J,Pengo M,Steier J

更新日期：2019-05-01 00:00:00

abstract：Background:To investigate the roles of gastrin-releasing peptide (ProGRP) in the diagnosis of small cell lung cancer (SCLC). Methods:We retrospectively analyzed data from 11,206 patients with clinical suspicion of lung cancer from January 1, 2015 to May 31, 2018. ProGRP and neuron-specific enolase (NSE) were detected ...

journal_title：Journal of thoracic disease

authors： Dong A,Zhang J,Chen X,Ren X,Zhang X

更新日期：2019-04-01 00:00:00

abstract：Background:Pacing parameters may influence pacing lead life and pacemaker life. This study sought to determine whether different right atrial active-fixation lead implantation parameters are associated with chronic pacing performance. Methods:A retrospective observational study was conducted on all consecutive patient...

journal_title：Journal of thoracic disease

authors： Chen MR,Zhang FL,Wang WW,Chen XH,Chen JH,Chen LL

更新日期：2019-04-01 00:00:00

abstract：Background:Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and morbidity around the world, with comorbidities in COPD being common and having a negative effect on survival. We investigate the effects of comorbidities on long-term survival of COPD patients. Methods:The study inclu...

journal_title：Journal of thoracic disease

authors： Eroglu SA,Gunen H,Yakar HI,Yildiz E,Kavas M,Duman D

更新日期：2019-04-01 00:00:00

abstract：Background:To assess possible differences in the perioperative profile between men and women in lung cancer surgery. Methods:A prospective cohort multicenter study was design, in which consecutive patients undergoing curative intent surgery for lung cancer in 24 Thoracic Services throughout Spain were included. Clinic...

journal_title：Journal of thoracic disease

authors： Fibla JJ,Molins L,Quero F,Izquierdo JM,Sánchez D,Hernández J,Bayarri C,Boada M,Guirao Á,Cueto A

更新日期：2019-04-01 00:00:00

abstract：Background:Vitamin C has shown several beneficial effects on sepsis in preclinical studies. However, clinical data supporting these reports are scarce. This study aimed to evaluate whether adjunctive intravenous vitamin C therapy could reduce hospital mortality in patients with severe sepsis or septic shock requiring m...

journal_title：Journal of thoracic disease

authors： Ahn JH,Oh DK,Huh JW,Lim CM,Koh Y,Hong SB

更新日期：2019-04-01 00:00:00

abstract：:The application of bronchoscopy has resolved a series of diagnostic and treatment challenges in pulmonary diseases. However, the occupational adverse effects experienced by healthcare workers in interventional pulmonology should receive increasing attention. Various aspects of adverse effects in bronchoscopy are often...

journal_title：Journal of thoracic disease

authors： Chen K,Bai C

更新日期：2019-04-01 00:00:00

abstract：:The severity of the clinical condition and co-morbidities of the patients for esophagectomy require a complex assessment and risk stratification before the operation, and most of the cases need complex management. We did a literature search and considered the data on risk stratification and complex management of patie...

journal_title：Journal of thoracic disease

authors： Varga JT

更新日期：2019-04-01 00:00:00